Postdoctoral Fellow-MSH-32035-051

JOB TITLE: Postdoctoral Fellow in Diabetes, Obesity and Metabolism Institute, Mount Sinai, NY

POSITION SUMMARY: The lab of Dr. Romina Bevacqua, an early-career Principal Investigator in the Diabetes,Obesity and Metabolism Institute, is seeking a curious, motivated, Postdoctoral Fellow interested in performingtransformative research on human diabetes and pancreatic islet biology. The broader significance of the work in Bevacqua Lab is that diabetes affects over 400 million people worldwide and advancing our understanding of adult human islet functionality, will lead to development of novel approaches for the treatment of diabetic patients. Morespecifically, Bevacqua Lab is interested in studying: 1) the regulatory mechanisms driving human islet maturation: 2)the genetic basis for their dysregulation in disease: and, 3) the application of these findings towards β-cellregeneration and replacement therapies. These approaches will include implementation of novel genetic approaches in vivo to reverse diabetes, and will open new possibilities for the treatment of patients with diabetes.

To address these topics, the lab uses cellular biology, including genetics on pseudoislet organoids derived from non-diving human islets, molecular biology, Next-gen sequencing (CUT&RUN, RNA-seq, ATAC-seq, Mi-seq), FACS of different islet cell populations, functional studies, islet transplantation approaches, and imaging.

Qualified candidates should be self-driven and independent, enthusiastic for team work, eager to work in afriendly environment, with a track record of success supported by first-author publications in related fields. The applicants should have a strong interest in basic and translational diabetes research.

The selected candidate for this full-time position will be expected to apply well-established protocols and develop novel ones to address basic or translational research questions in diverse areas of pancreatic islet cell biology,including diverse NGS technologies, CRISPR screenings and novel CRISPR -or similar- genetic approaches. This postdoctoral opportunity will enable training in development of cutting-edge experimental methods. Theselected candidate will have the opportunity to participate in collaborative projects with multiple institutions fromNorth America and Europe.

Lab Website: https://labs.icahn.mssm.edu/bevacqualab/

GENERAL DUTIES

• Design and perform research studies;
• Perform high-throughput data analysis;
• Prepare figures and manuscripts;
• Apply for external fellowship competition;
• Contribute to grant applications

• Supervise and train graduate students;
• Present work at internal, local, national and international meetings;
• Perform ongoing literature review to remain current with new procedures, computational tools and related research; propose new research directions based on the advances discussed in literature.

• Recent PhD in Cellular Biology, Diabetes, Genetics, Genomics, Molecular Biology, Biochemistry,Bioengineering, Bioinformatics, Computational Biology or related field;
• Experience in molecular biology techniques and high-throughput experimental methods (preferred);
• Experience in cell culture and mice handling (preferred);
• Goal-oriented and self-motivated with excellent verbal and written scientific communication skills;
• Excellent organizational and project management skills;
• Strong problem-solving skills;
• Able to work well in multidisciplinary and collaborative research environment;

• A track record of conference presentations and first author peer-reviewed publications.

In order to apply for the position, please submit:

-2 references;

-Cover letter briefly describing candidate?s research experience, major contributions to the field, researchinterests and fit for this position;

-CV

** Please submit your CV, cover letter and 2 letters of reference in a single PDF or Word document to romina.bevacqua@mssm.edu