Postdoctoral Fellow-MSH-30001-321

Postdoctoral Research Scientist Position

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai

Are you passionate about unraveling the mysteries of proteins and their roles in diseases like Alzheimer’s and cancer? Dr. Wei Wang’s lab at the Icahn School of Medicine at Mount Sinai is seeking motivated Postdoctoral Research Scientists to dive into groundbreaking structural biology research. Gain hands-on experience with cutting-edge techniques like cryo-EM and X-ray crystallography in a collaborative environment. This is an incredible opportunity for recent graduates to enhance their skills and contribute to high-impact projects.

Ready to make a difference? Apply now and be a part of our team!

Position Summary:

As a Postdoctoral Research Scientist, you will contribute to the investigation of the structure and dynamics of disease-related proteins using single-particle cryo-EM, X-ray diffraction, and molecular simulations. You will also participate in structure-assisted drug design in collaboration with computational scientists. This role offers the opportunity to join a multidisciplinary team dedicated to advancing time-resolved structural biology techniques to understand and manipulate the structure, function, and dynamics of drug targets.

Key Responsibilities:

• Employ structural biology techniques to study and understand the structure, function, and dynamics of disease-related proteins and protein-ligand complexes.
• Contribute to structure-assisted drug design.
• Perform molecular dynamics simulations and QM/MM calculations.
• Publish research findings in peer-reviewed journals and present results at national and international conferences.
• Mentor graduate and undergraduate students.
• Contribute to grant proposals and progress reports.

What We Offer:

• Comprehensive training in structural biology techniques such as cryo-EM and protein crystallization.
• An opportunity to contribute to high-impact research projects in the fields of neurodegenerative diseases and oncology.
• A supportive environment for skill development and career growth.
• Mentorship from senior lab members and access to state-of-the-art research facilities.

How to apply:

Please submit a single PDF containing your cover letter, curriculum vitae, and a list of publications when applying for this position. In your cover letter, briefly describe your research experience, career goals, and how your expertise aligns with this position. Additionally, include contact information for at least two references. Applications should be emailed to <wei.wang@mssm.edu> with your full name and the job position title in the subject line. Applications will be reviewed on a rolling basis, and selected candidates will be required to provide at least two confidential letters of reference.

Please read following information about this opportunity to learn more.

Required Qualifications:

• Ph.D. in structural biology, biochemistry, biophysics, or related fields such as chemistry, physical chemistry, or biological structure research, completed within the last three years.
• Proficiency in protein expression and purification in eukaryotic and prokaryotic systems.
• Experience in single-particle cryo-EM or crystallization (or both), including structure determination and analysis of protein-ligand complexes.
• Ability to interact effectively with research staff at all levels and work within a multidisciplinary team.
• Good interpersonal, communication, and presentation skills.

Preferred Qualifications:

• Experience and knowledge in structure-based drug design.
• Proficiency in Python programming and its applications in structural biology.
• Experience with other biophysical characterization methods.
• A record of productive and creative research, demonstrated by publications in peer-reviewed journals and presentations at scientific conferences.

Physical Requirements:

• Ability to perform experiments while seated or standing for extended periods.
• Dexterity to manipulate small laboratory tools and reagents.
• Occasionally involves light physical effort such as moving laboratory equipment or handling reagents.

816 - Genetics/Genomic Sci - ISM, Icahn School of Medicine