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Trustees of University of Pennsylvania

Research Specialist C/D (Department of Rheumatology)

3400 Spruce Street, Philadelphia, PA 19104

Full-time · $58k–$77k (as posted)

First seen by offpeak October 21, 2026

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University Overview

The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn’s distinctive interdisciplinary approach to scholarship and learning. As an employer Penn has been ranked nationally on many occasions with the most recent award from Forbes who named Penn one of America’s Best Large Employers in 2023.

Penn offers a unique working environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide variety of atmospheres, Philadelphia is the perfect place to call home for work and play.

The University offers a competitive benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and resources, and much more.

Posted Job Title

Research Specialist C/D (Department of Rheumatology)

Job Profile Title

Research Specialist C

Job Description Summary

We are looking for a highly motivated, dedicated and enthusiastic individual who has a strong background in molecular cloning, recombinant protein production, and immunology. The research specialist will be working closely with the Principal Investigator and other lab members on publication-generating projects to understand immune dysregulation in autoimmune diseases. The research specialist will generate and optimize protocols for recombinant protein production and help develop new approaches for detecting autoreactive, virus-specific, and cross-reactive T cells. It is expected that the research specialist will have expertise in producing and purifying recombinant proteins from bacterial, insect cell, mammalian systems. He/she should have computational
background for high-dimensional protein expression, RNA sequencing, and TCR sequencing data analyses. The research specialist will enjoy a high level of independence and be able to take a lead on projects. We are team-oriented and collaborative.

Job Description

Job Responsibilities

Research Specialist C

Research specialist C will be expected to plan and conduct complex experiments to meet research project objectives. These include producing and purifying recombinant proteins independently using various expression platforms, expertise in molecular cloning to generate expression constructs for new proteins, and the skillset to trouble shoot and optimize experiments. Familiarity with tissue culture and the ability to operate flow cytometer independently will be required.

Research Specialist D

In addition to qualifications outlined under Research specialist C, Research specialist D will be expected to also be proficient in bioinformatic tools and programming languages (e.g., R, Python). He/she will develop new techniques
for single-cell antigen-specific T cell analyses and independently perform high-dimensional protein expression, RNA sequencing, and TCR sequencing data analyses. Additionally, Research specialist D will assist with manuscript/grant writing and provide training to students in the laboratory.

Position Contingent Upon Funding

Qualifications

Research Specialist C

Bachelor of Science and 3 to 5 years of experience or equivalent combination of education and experience is required.

Research Specialist D

Master of Science and 3 to 5 years of experience or equivalent combination of education and experience is required.

Preferred:

Excellent organizational and record keeping skills.
 

Job Location - City, State

Philadelphia, Pennsylvania

Department / School

Perelman School of Medicine

Pay Range

$57,500.00 - $76,973.00 Annual Rate

Salary offers are made based on the candidate’s qualifications, experience, skills, and education as they directly relate to the requirements of the position, and in alignment with salary ranges based on external market data for the job’s level. Internal organization and peer data at Penn are also considered.

Equal Opportunity Statement 

The University of Pennsylvania is an equal opportunity employer. Candidates are considered for employment without regard to race, color, sex, sexual orientation, religion, creed, national origin (including shared ancestry or ethnic characteristics), citizenship status, age, disability, veteran status or any class protected under applicable federal, state or local law.

Special Requirements 
Background checks may be required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.

University Benefits

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To learn more, please visit: https://www.hr.upenn.edu/PennHR/benefits-pay 

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