Postdoctoral Fellow - Precision Oncology of Gastrointestinal Cancers

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.

Are you passionate about Gastroenterology Cancer research? Do you have a track record of published articles documenting your groundbreaking work? Join us in our mission to make a world of difference!

Led by Dr. Ajay Goel, Professor and Founding Chair of the Department of Molecular Diagnostics and Experimental Therapeutics, our multidisciplinary research group comprises basic researchers, gastroenterologists, surgeons, oncologists, and bioinformaticians, and undertakes several collaborative projects with large international consortia.

Our research focuses on translational studies of the genomic and epigenomic characterization of various gastrointestinal cancers (GI), including colorectal, pancreatic, gastric, esophageal, and hepatocellular cancers. Our group performs cutting-edge research in GI oncology, is very productive, and publishes in high-impact journals such as Nature Cancer, Nature Communications, Nature Biotechnology, Nature Reviews Gastroenterology and Hepatology, New England Journal of Medicine, CA: A Journal for Clinicians, Gastroenterology, Cancer Cell, PNAS, JAMA Oncology, JNCI, Cancer Research, Clinical Cancer Research, , Annals of Surgery, etc.

If you are interested, please send your CV directly to Dr. Goel at ajgoel@coh.org.

If you are passionate about some of the following things we are working on this may be the perfect opportunity:

·         Development of cell-free DNA (mutation and methylation), RNA, and exosomal-based liquid assays for early cancer detection, prognosis, and predictive responses to chemotherapies and targeted drugs.

·         Studying the genetic and epigenetic basis of GI cancers (e.g., aberrant DNA methylation, histone modifications, and non-coding RNAs).

·         Understanding the biological implications of the gut microbiome and its translational application in gastrointestinal cancers

·         The genetic basis of early-onset colorectal cancer (EO-CRC) and familial/hereditary colorectal cancer.

·         The role of extracellular vesicles/exosomes in cancer pathogenesis and their role as disease biomarkers.

·         The role of the tumor microenvironment, stem cells, immune regulation, and identification of novel targeted therapies.

·         Cancer prevention and adjunctive role of natural and integrative therapy approaches.

As a successful candidate, you will:

·         Devise, plan, document, and advance basic science and translational projects in genetics, epigenetics, and precision oncology of gastrointestinal cancers.

·         Generate data for grant applications and prepare manuscripts for publication.

·         Work closely with other team members and external collaborators, including presenting progress internally or externally.

·         Ability to work in a fast-paced team environment and handle multiple projects simultaneously.