Codexis
Principal Process Engineer
200 Penobscot Drive, Redwood City, CA 75024
On-site · Full-time · $165k–$185k (as posted)
First seen by offpeak October 6, 2026
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If any of the below describes you, we would love to meet you!
- Possess a passion for being part of the therapeutic community helping bring cutting edge treatments to patients in need.
- Enjoys collaboration across different functional groups to get a holistic understanding of process development along with aligning data with internal stakeholders.
- Enjoys problem solving by implementing engineering and analytical solutions.
Key Responsibilities
- Providing technical leadership in hands‑on process development, applying advanced engineering principles to drive the design, build‑out, and maturation of the ECO Synthesis® platform in close partnership with cross‑functional development teams
- Leading the scale‑up strategy for the ECO Synthesis® platform, ensuring process is robust, well‑characterized, and ready for transition into a cGMP manufacturing environment.
- Championing laboratory safety, maintaining a clean and compliant workspace, conducting process hazard analyses and risk assessments, and ensuring safe working environment for all team members.
- Overseeing documentation quality, ensuring batch records, SOPs, and development reports meet GDP standards; providing mentorship and guidance to early‑career engineers and scientists on documentation and experimental/statistical rigor.
- Leading the development and delivery of key technical work, including internal and external presentations, detailed technical reports, and comprehensive technology transfer packages for siRNA manufacturing processes.
- Owning the creation of engineering design tools, including mass and energy balances, process flow diagrams (PFDs), equipment specifications, and cost models to support scale‑up, facility integration, and long‑term platform deployment.
- Serving as primary technical liaison with external vendors, driving equipment selection, qualification, and support activities essential for effective process development and scale‑up.
Skills, Knowledge & Expertise
• Bachelor’s degree in Chemical Engineering, Biochemical Engineering, or related field with 10+ years of relevant industrial experience, or M.S. with 8+ years.• Expertise in flow chemistry, biocatalysis, or oligonucleotide synthesis technologies (e.g., SPOS, enzymatic platforms).
• Demonstrated leadership in scale‑up activities, including tech transfer of biocatalytic or nucleic acid–based processes from laboratory to pilot or commercial manufacturing environments.
• Proficiency in process modeling and simulation tools such as Aspen Plus, SuperPro Designer, COMSOL, or DynoChem; and proficient with data analytics or scripting tools (e.g., R, JMP, Python).
• Strong leadership, communication skills, with the ability to collaborate effectively across cross-functional teams including R&D, Operations, Quality, and Engineering.
Additional experience that would be valuable for this role includes: • Prior experience managing early career engineers, scientist, or research associates. • Expertise in purification technologies, such as chromatography, filtration, or enzyme/oligonucleotide purification workflows. • Experience with facility design or equipment specification, for nucleic acid manufacturing. • Deep understanding of quality systems and regulatory expectations, including ISO-based quality frameworks and GMP principles.
Job Benefits
- Medical, Dental and Vision Insurance
- Basic Life, AD&D, Short- and Long-Term Disability Insurance
- 401k with Company Match up to 4%
- Company Equity
- Generous Paid Time Off including 18 Company Holidays (with a summer and winter shutdown), Vacation, and Wellness Time
- Annual Lifestyle Account for reimbursement of fitness programs, equipment and more
- Employee Stock Purchase Program (ESPP)
- Flexible Spending Accounts (Commuter/Parking, Dependent Care & Healthcare)
- Student Debt Program (Company Contribution to Loans)
- Mental Health Wellness Program
- Subsidized onsite lunch program
- Onsite Gym Facilities
- Paid Parental Leave