Clinical Research Manager II

Where Purpose Meets Progress

At the Minneapolis Heart Institute Foundation (MHIF), your work supports patient-centered care and helps advance cardiovascular research and education. As a Clinical Research Manager II (CRM II), you will do more than oversee research operations—you will provide strategic leadership, build high-performing teams, and strengthen the partnerships and programs that help change and save lives.

Summary

At Minneapolis Heart Institute Foundation, we believe our people are our greatest asset and our culture is what sets us apart. Every role contributes to advancing cardiovascular care through research, education, and trusted partnerships, and every employee plays an important role in improving lives around the world. We are committed to fostering a collaborative, innovative, and mission-driven workplace where people feel valued, supported, and empowered to grow.

The Clinical Research Manager II (CRM II) provides advanced managerial and strategic leadership for large, complex clinical research and education portfolios across multiple domains. This role partners closely with Principal Investigators, research teams, executive leadership, physicians, and industry collaborators to shape portfolio strategy, optimize resources, and advance organizational priorities.

The CRM II leads enterprise-wide initiatives, drives cross-functional collaboration and integration, mentors research staff and other Clinical Research Managers, and may oversee shared services or multiple enterprise-level functions. This role balances day-to-day operational oversight with long-term planning, financial stewardship, innovation, and external relationship management.

Primary Responsibilities

Portfolio Strategy & Operations

• Oversee large, complex clinical research and education portfolios across multiple domains.
• Partner with Principal Investigators and organizational leaders to influence portfolio strategy, long-term planning, and innovation.
• Ensure research programs align with MHIF’s long-term vision, organizational goals, and standards of quality and compliance.
• Lead strategic planning, resource utilization, and resource allocation for complex portfolios.
• Monitor operational performance, address advanced issues, and implement solutions that strengthen efficiency, engagement, and outcomes.
• Support the financial health of assigned portfolios through sound business judgment, planning, and oversight.
• Maintain awareness of applicable clinical research regulatory requirements and compliance standards.

Enterprise Leadership & Integration

• Lead one or more enterprise-wide projects and initiatives with broad organizational impact.
• Drive cross-functional collaboration, strategic integration, and alignment across research programs and operational functions.
• Oversee shared services teams or other functional groups in support of organizational initiatives, as assigned.
• May expand to oversee multiple enterprise-level functions and lead integration across programs.
• Sponsor and influence projects that advance innovation, optimization, and collaboration across research specialties.
• Collaborate with executive leadership to identify opportunities, address organizational priorities, and support sustainable growth.

Team Leadership & Development

• Provide direct supervision and leadership for research staff and may lead cross-functional teams as portfolio needs expand.
• Build engaged, high-performing teams through clear expectations, accountability, coaching, and performance management.
• Mentor research staff and other Clinical Research Managers, fostering professional development, succession readiness, and talent growth.
• Lead multidisciplinary teams and create a culture of collaboration, trust, continuous improvement, and shared accountability.
• Champion effective team utilization and engagement across complex research portfolios.

External Partnerships & Representation

• Secure and build strategic partnerships with industry and other external collaborators.
• Manage complex relationships with leading industry partners through proactive communication, advanced troubleshooting, and effective problem resolution.
• Represent MHIF externally with physicians, industry partners, and other stakeholders as appropriate.
• Identify and pursue opportunities to strengthen funding strategy, research partnerships, and organizational visibility.
• Support external representation that advances MHIF’s research, education, and mission-driven priorities.

Core Values in Action

At MHIF, our values are not just words—they guide how we lead and work together:

• Integrity: Do the right thing, even when it is hard. Operate ethically and transparently.
• Innovation: Ask bold questions. Be proactive and curious in improving how we work.
• Collaboration: Support one another, build trust, and celebrate success as one team.
• Excellence: Own your work. Be accountable. Bring urgency and resilience to solving problems.

What Sets You Apart

• Bachelor’s degree in life sciences, healthcare, business, or a related field required; master’s degree or higher preferred.
• Minimum of 5 years of progressive experience in clinical research people management or related leadership roles.
• Demonstrated experience managing complex clinical research and education portfolios.
• Proven success in project management, strategic planning, team leadership, and cross-functional collaboration.
• Experience securing external funding and building strategic partnerships with industry or other external stakeholders.
• Strong business acumen, financial planning skills, and ability to manage resources across complex portfolios.
• Experience leading enterprise-wide projects, multidisciplinary teams, or multiple functional areas.
• Strong written, verbal, and presentation communication skills, with the ability to engage diverse internal and external stakeholders.
• Advanced problem-solving, organizational, relationship-management, and decision-making abilities.
• Commitment to professional development, innovation, compliance, and external representation.

Knowledge, Skills & Abilities

• Strategic vision with the ability to translate organizational priorities into practical plans and measurable results.
• Strong leadership skills, including culture stewardship, change leadership, team development, and performance management.
• Ability to lead innovation and integration across programs, specialties, and enterprise-level functions.
• Expertise in collaboration, stakeholder engagement, and cross-functional team management.
• Ability to balance short-term operational needs with long-term portfolio strategy and organizational impact.
• Sound financial and business judgment, including resource planning and allocation.
• Ability to foster high-performing teams and mentor leaders at multiple levels.
• Confidence representing the organization externally and providing strategic counsel to executive leadership.

Total Rewards

In addition to meaningful, mission-driven work, MHIF offers:

• Competitive annual salary: $125,000 - $135,000
• Comprehensive benefits including: Medical, dental, and vision insurance
• Life, short- and long-term disability
• Employer HSA contribution
• 401(k) with employer match and contribution
• Generous PTO, paid holidays, and parental leave
• Tuition reimbursement and paid volunteer time

Why Join MHIF?

“Small team. Global impact.”

Here, your work has purpose. Your voice is heard. Your career can grow. As a Clinical Research Manager II, you will help shape the strategy, partnerships, and people behind research and education programs that advance cardiovascular care.

We are driven by discovery and grounded in compassion—and we are looking for someone who brings both leadership and expertise to the table.

Ready to do work that matters?