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St. Jude Children's Research Hospital, Inc.

Principal Computational Engineer

501 St Jude Pl, Memphis, TN 38105-1905

Full-time · $114k–$216k (as posted)

First seen by offpeak October 4, 2026

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St. Jude Children's Research Hospital is seeking a Principal Computational Engineer to provide technical leadership and strategic vision for the advanced computing environments and software ecosystems leveraged by researchers to further the St. Jude mission. This role serves as a senior technical leader within High Performance Research Computing (HPRC), partnering closely with researchers, data scientists, software engineers, and institutional stakeholders to define and execute institutional research computing strategy.

The Principal Computational Engineer will lead the design, evaluation, and implementation of scalable scientific computing solutions spanning high-performance computing (HPC), cloud computing, research software engineering, data-intensive workflows, artificial intelligence and machine learning platforms, and advanced data management systems. The successful candidate will possess a strong understanding of the computational challenges associated with modern life science research and ideally have experience supporting research environments that facilitate bioinformatics, genomics, imaging, structural biology, computational biology, or other data-intensive scientific workflows.

As a trusted technical advisor, this individual will help research programs leverage advanced computational technologies while ensuring solutions are sustainable, secure, scalable, and aligned with institutional objectives. The role requires a unique combination of expertise in computational science, software development, research computing infrastructure, and collaborative engagement with multidisciplinary teams. The Principal Computational Engineer will guide architectural decisions, evaluate emerging technologies, mentor engineering team members, and translate complex scientific requirements into robust computational capabilities that support research across St. Jude.

Job Responsibilities:


Minimum Education and/or Training:


Minimum Experience:

Desired/Highly Preferred Experience:


Special Skills, Knowledge and Abilities:

Compensation

In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $114,400 - $216,320 per year for the role of Principal Computational Engineer.

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St. Jude is an Equal Opportunity Employer

No Search Firms

St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.